VirtualBox - Can I use a non supported HW which is not supported by my host OS in my guest OS?

I am trying to use an external wireless antenna (Alfa Network AWUS036H) with a Linux VirtualBox virtual machine but it doesn't work.

I can see the antenna by clicking on Devices > USB but when I try to attach it to virtual machine, nothing happens.

My host is running OSX El Capitan which doesn't support this HW.

Is it possible to use a HW which is not supported by the host OS at all?

Edited:

5 minutes later I got this error: NS_ERROR_FAILURE (0x80004005)