Registration-free COM works on a local machine, but throws exception in Azure App Service

Trying to use a COM library in Azure App Service. The library is 32-bit, and the service is configured to run in 32-bit as well.

In order to make it run on a local machine without registration I've created a manifest file, as well as copied custom activation code from the examples found at https://www.manifestmaker.com/sxs/help/iis_aspnet.htm. This way the dll is successfully loaded and activated on a local machine without COM registration.

<?xml version="1.0" encoding="utf-8"?>
<assembly manifestVersion="1.0" xmlns="urn:schemas-microsoft-com:asm.v1" xmlns:asmv2="urn:schemas-microsoft-com:asm.v2" xmlns:dsig="http://www.w3.org/2000/09/xmldsig#">
  <assemblyIdentity name="pp_cli_com_lib" version="1.0.0.0" type="win32" />
  <file name="pp_cli_com.dll" asmv2:size="460800">
    <hash xmlns="urn:schemas-microsoft-com:asm.v2">
      <dsig:Transforms>
        <dsig:Transform Algorithm="urn:schemas-microsoft-com:HashTransforms.Identity" />
      </dsig:Transforms>
      <dsig:DigestMethod Algorithm="http://www.w3.org/2000/09/xmldsig#sha1" />
      <dsig:DigestValue>JQXRI2IOR9A7KAn4+yW8n9pGMz0=</dsig:DigestValue>
    </hash>
    <typelib tlbid="{85796a56-cee8-426a-81e2-c896d7b3dbbd}" version="1.0" helpdir="" resourceid="0" flags="HASDISKIMAGE" />
    <comClass clsid="{6d7c883b-9cca-4fc1-badb-fdc367b44ae7}" threadingModel="Apartment" tlbid="{85796a56-cee8-426a-81e2-c896d7b3dbbd}" progid="Pp_cli_com.KCP.1" description="KCP Class" />
  </file>
</assembly>

            var wmh = new WebManifestHelper();
            var activated = wmh.ActivateWebManifest("pp_cli_com_lib.manifest");
            if (!activated)
            {
                throw new InvalidOperationException($"Unable to activate! Error code: {wmh.dwError}.");
            }
            var kcpObject = new PP_CLI_COMLib.KCP();

However when trying to do the same in Azure App Service I get the following error:

[FileLoadException: Retrieving the COM class factory for component with CLSID {6D7C883B-9CCA-4FC1-BADB-FDC367B44AE7} failed due to the following error: 8007045a A dynamic link library (DLL) initialization routine failed. (Exception from HRESULT: 0x8007045A).] System.RuntimeTypeHandle.CreateInstance(RuntimeType type, Boolean publicOnly, Boolean noCheck, Boolean& canBeCached, RuntimeMethodHandleInternal& ctor, Boolean& bNeedSecurityCheck) +0 System.RuntimeType.CreateInstanceSlow(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark) +122 System.RuntimeType.CreateInstanceDefaultCtor(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache, StackCrawlMark& stackMark) +239 System.Activator.CreateInstance(Type type, Boolean nonPublic) +85 System.Activator.CreateInstance(Type type) +12

Does it mean that this particular COM library is not compatible with the Azure App Service sandbox environment?

When you create azure app server, the default options of Publish is Code which use sandbox environment.

So the webapp created by default not support Registration-free Com.

But Azure App Service supports Windows Containers, you can customize the container.