Python expresses a number as a really large integer rather than a negative number

Is there a way to force python to treat a number based upon its sign?

E.g. 0xFFFFFFFF = -1 instead of 4294967295?

You can use ctypes.c_int32 for a signed 32 bit integer:

import ctypes
wrapped = ctypes.c_int32(0xFFFFFFFF)
print(wrapped) # c_int(-1)
print(wrapped.value) # -1