Virtualbox - Fails to start with exit code -1073741819 (0xc0000005)

I'm not able to start any VM on a fresh Virtualbox install.

I am running Windows 10 Pro, with Virtualisation enabled, Hyper-V disabled.

This is a work computer, so it has some software (Cylance) in place that blocks unusual activity.

The IT team has whitelisted any Virtualbox related activity, but still no luck.

Error Message when attempting to start a blank VM:

Failed to open a session for the virtual machine Test.

The virtual machine 'Test' has terminated unexpectedly during startup with exit code -1073741819 (0xc0000005). More details may be available in 'C:\Users\qqqq\VirtualBox VMs\Test\Logs\VBoxHardening.log'.

Result Code: E_FAIL (0x80004005)

Component: MachineWrap

Interface: IMachine {85cd948e-a71f-4289-281e-0ca7ad48cd89}

VBoxHardening.log

2cb4.2024: Log file opened: 5.2.16r123759 g_hStartupLog=0000000000000048 g_uNtVerCombined=0xa0383900
2cb4.2024: \SystemRoot\System32\ntdll.dll:
2cb4.2024:     CreationTime:    2018-03-22T15:00:45.814277600Z
2cb4.2024:     LastWriteTime:   2017-09-07T06:03:35.589628500Z
2cb4.2024:     ChangeTime:      2018-09-08T14:12:29.986368600Z
2cb4.2024:     FileAttributes:  0x20
2cb4.2024:     Size:            0x1cccb0
2cb4.2024:     NT Headers:      0xd8
2cb4.2024:     Timestamp:       0x59b0d03e
2cb4.2024:     Machine:         0x8664 - amd64
2cb4.2024:     Timestamp:       0x59b0d03e
2cb4.2024:     Image Version:   10.0
2cb4.2024:     SizeOfImage:     0x1d2000 (1908736)
2cb4.2024:     Resource Dir:    0x169000 LB 0x67a50
2cb4.2024:     [Version info resource found at 0xd8! (ID/Name: 0x1; SubID/SubName: 0x409)]
2cb4.2024:     [Raw version resource data: 0x1690f0 LB 0x398, codepage 0x0 (reserved 0x0)]
2cb4.2024:     ProductName:     Microsoft® Windows® Operating System
2cb4.2024:     ProductVersion:  10.0.14393.1715
2cb4.2024:     FileVersion:     10.0.14393.1715 (rs1_release_inmarket.170906-1810)
2cb4.2024:     FileDescription: NT Layer DLL
2cb4.2024: \SystemRoot\System32\kernel32.dll:
2cb4.2024:     CreationTime:    2018-03-22T15:01:05.163162300Z
2cb4.2024:     LastWriteTime:   2017-04-28T00:49:43.332433600Z
2cb4.2024:     ChangeTime:      2018-09-08T14:12:29.548635100Z
2cb4.2024:     FileAttributes:  0x20
2cb4.2024:     Size:            0xab208
2cb4.2024:     NT Headers:      0xf0
2cb4.2024:     Timestamp:       0x59028368
2cb4.2024:     Machine:         0x8664 - amd64
2cb4.2024:     Timestamp:       0x59028368
2cb4.2024:     Image Version:   10.0
2cb4.2024:     SizeOfImage:     0xac000 (704512)
2cb4.2024:     Resource Dir:    0xaa000 LB 0x530
2cb4.2024:     [Version info resource found at 0x90! (ID/Name: 0x1; SubID/SubName: 0x409)]
2cb4.2024:     [Raw version resource data: 0xaa0b0 LB 0x3b4, codepage 0x0 (reserved 0x0)]
2cb4.2024:     ProductName:     Microsoft® Windows® Operating System
2cb4.2024:     ProductVersion:  10.0.14393.1198
2cb4.2024:     FileVersion:     10.0.14393.1198 (rs1_release_sec.170427-1353)
2cb4.2024:     FileDescription: Windows NT BASE API Client DLL
2cb4.2024: \SystemRoot\System32\KernelBase.dll:
2cb4.2024:     CreationTime:    2018-09-08T14:03:13.622042800Z
2cb4.2024:     LastWriteTime:   2018-03-02T09:07:30.254111800Z
2cb4.2024:     ChangeTime:      2018-09-11T09:45:16.120231900Z
2cb4.2024:     FileAttributes:  0x20
2cb4.2024:     Size:            0x21c780
2cb4.2024:     NT Headers:      0xf8
2cb4.2024:     Timestamp:       0x5a9906f8
2cb4.2024:     Machine:         0x8664 - amd64
2cb4.2024:     Timestamp:       0x5a9906f8
2cb4.2024:     Image Version:   10.0
2cb4.2024:     SizeOfImage:     0x21d000 (2215936)
2cb4.2024:     Resource Dir:    0x201000 LB 0x550
2cb4.2024:     [Version info resource found at 0x90! (ID/Name: 0x1; SubID/SubName: 0x409)]
2cb4.2024:     [Raw version resource data: 0x2010b0 LB 0x3c4, codepage 0x0 (reserved 0x0)]
2cb4.2024:     ProductName:     Microsoft® Windows® Operating System
2cb4.2024:     ProductVersion:  10.0.14393.2125
2cb4.2024:     FileVersion:     10.0.14393.2125 (rs1_release.180301-2139)
2cb4.2024:     FileDescription: Windows NT BASE API Client DLL
2cb4.2024: \SystemRoot\System32\apisetschema.dll:
2cb4.2024:     CreationTime:    2018-09-08T14:01:39.376840700Z
2cb4.2024:     LastWriteTime:   2018-03-02T09:07:28.044323200Z
2cb4.2024:     ChangeTime:      2018-09-11T09:45:13.322698900Z
2cb4.2024:     FileAttributes:  0x20
2cb4.2024:     Size:            0x18960
2cb4.2024:     NT Headers:      0xc8
2cb4.2024:     Timestamp:       0x5a990a54
2cb4.2024:     Machine:         0x8664 - amd64
2cb4.2024:     Timestamp:       0x5a990a54
2cb4.2024:     Image Version:   10.0
2cb4.2024:     SizeOfImage:     0x19000 (102400)
2cb4.2024:     Resource Dir:    0x18000 LB 0x400
2cb4.2024:     [Version info resource found at 0x48! (ID/Name: 0x1; SubID/SubName: 0x409)]
2cb4.2024:     [Raw version resource data: 0x18060 LB 0x3a0, codepage 0x0 (reserved 0x0)]
2cb4.2024:     ProductName:     Microsoft® Windows® Operating System
2cb4.2024:     ProductVersion:  10.0.14393.2125
2cb4.2024:     FileVersion:     10.0.14393.2125 (rs1_release.180301-2139)
2cb4.2024:     FileDescription: ApiSet Schema DLL
2cb4.2024: NtOpenDirectoryObject failed on \Driver: 0xc0000022
2cb4.2024: supR3HardenedWinFindAdversaries: 0x8000
2cb4.2024: \SystemRoot\System32\drivers\cyprotectdrv64.sys:
2cb4.2024:     CreationTime:    2017-12-14T15:28:01.417258000Z
2cb4.2024:     LastWriteTime:   2018-09-05T21:08:37.658055300Z
2cb4.2024:     ChangeTime:      2018-09-11T11:59:17.884170200Z
2cb4.2024:     FileAttributes:  0x20
2cb4.2024:     Size:            0x32db0
2cb4.2024:     NT Headers:      0x100
2cb4.2024:     Timestamp:       0x5b7efd1c
2cb4.2024:     Machine:         0x8664 - amd64
2cb4.2024:     Timestamp:       0x5b7efd1c
2cb4.2024:     Image Version:   6.1
2cb4.2024:     SizeOfImage:     0x132000 (1253376)
2cb4.2024:     Resource Dir:    0x130000 LB 0x2f0
2cb4.2024:     [Version info resource found at 0x48! (ID/Name: 0x1; SubID/SubName: 0x409)]
2cb4.2024:     [Raw version resource data: 0x130060 LB 0x28c, codepage 0x0 (reserved 0x0)]
2cb4.2024:     ProductName:     CylancePROTECT
2cb4.2024:     ProductVersion:  2.0.1494.43
2cb4.2024:     FileVersion:     2.0.1494.43
2cb4.2024:     FileDescription: Cylance Protect Driver
2cb4.2024: supR3HardenedWinInitAppBin(0x0): '\Device\HarddiskVolume2\Program Files\Oracle\VirtualBox'
2cb4.2024: Calling main()
2cb4.2024: SUPR3HardenedMain: pszProgName=VirtualBox fFlags=0x2
2cb4.2024: supR3HardenedWinInitAppBin(0x2): '\Device\HarddiskVolume2\Program Files\Oracle\VirtualBox'
2cb4.2024: SUPR3HardenedMain: Respawn #1
2cb4.2024: System32:  \Device\HarddiskVolume2\Windows\System32
2cb4.2024: WinSxS:    \Device\HarddiskVolume2\Windows\WinSxS
2cb4.2024: KnownDllPath: C:\windows\System32
2cb4.2024: '\Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe' has no imports
2cb4.2024: supHardenedWinVerifyImageByHandle: -> 0 (\Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe)
2cb4.2024: supR3HardNtEnableThreadCreation:
2cb4.2024: supR3HardNtDisableThreadCreation: pvLdrInitThunk=00007ffed1a69f60 pvNtTerminateThread=00007ffed1a96af0
2cb4.2024: supR3HardenedWinDoReSpawn(1): New child 203c.2e54 [kernel32].
2cb4.2024: supR3HardNtChildGatherData: PebBaseAddress=0000000000f4f000 cbPeb=0x388
2cb4.2024: supR3HardNtPuChFindNtdll: uNtDllParentAddr=00007ffed19f0000 uNtDllChildAddr=00007ffed19f0000
2cb4.2024: supR3HardenedWinSetupChildInit: uLdrInitThunk=00007ffed1a69f60
2cb4.2024: supR3HardenedWinSetupChildInit: Start child.
2cb4.2024: supR3HardNtChildWaitFor: Found expected request 0 (PurifyChildAndCloseHandles) after 0 ms.
2cb4.2024: supR3HardNtChildPurify: Startup delay kludge #1/0: 517 ms, 60 sleeps
2cb4.2024: supHardNtVpScanVirtualMemory: enmKind=CHILD_PURIFICATION
2cb4.2024:  *0000000000000000-0000000000c4ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000c50000-0000000000c6ffff 0x0004/0x0004 0x0020000
2cb4.2024:  *0000000000c70000-0000000000c85fff 0x0002/0x0002 0x0040000
2cb4.2024:   0000000000c86000-0000000000c8ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000c90000-0000000000d8afff 0x0000/0x0004 0x0020000
2cb4.2024:   0000000000d8b000-0000000000d8dfff 0x0104/0x0004 0x0020000
2cb4.2024:   0000000000d8e000-0000000000d8ffff 0x0004/0x0004 0x0020000
2cb4.2024:  *0000000000d90000-0000000000d93fff 0x0002/0x0002 0x0040000
2cb4.2024:   0000000000d94000-0000000000d9ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000da0000-0000000000da1fff 0x0004/0x0004 0x0020000
2cb4.2024:   0000000000da2000-0000000000daffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000db0000-0000000000db0fff 0x0020/0x0020 0x0020000 !!
2cb4.2024: supHardNtVpFreeOrReplacePrivateExecMemory: Freeing exec mem at 0000000000db0000 (LB 0x1000, 0000000000db0000 LB 0x1000)
2cb4.2024: supHardNtVpFreeOrReplacePrivateExecMemory: Free attempt #1 succeeded: 0x0 [0000000000db0000/0000000000db0000 LB 0/0x1000]
2cb4.2024: supHardNtVpFreeOrReplacePrivateExecMemory: QVM after free 0: [0000000000000000]/0000000000db0000 LB 0x50000 s=0x10000 ap=0x0 rp=0x00000000000001
2cb4.2024:   0000000000db1000-0000000000dfffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000e00000-0000000000f4efff 0x0000/0x0004 0x0020000
2cb4.2024:   0000000000f4f000-0000000000f51fff 0x0004/0x0004 0x0020000
2cb4.2024:   0000000000f52000-0000000000ffffff 0x0000/0x0004 0x0020000
2cb4.2024:   0000000001000000-000000007ffdffff 0x0001/0x0000 0x0000000
2cb4.2024:  *000000007ffe0000-000000007ffe0fff 0x0002/0x0002 0x0020000
2cb4.2024:   000000007ffe1000-000000007ffeffff 0x0000/0x0002 0x0020000
2cb4.2024:   000000007fff0000-00007ff60829ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ff6082a0000-00007ff6082c2fff 0x0002/0x0002 0x0040000
2cb4.2024:   00007ff6082c3000-00007ff608b1ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ff608b20000-00007ff608b20fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608b21000-00007ff608b91fff 0x0020/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608b92000-00007ff608b92fff 0x0080/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608b93000-00007ff608bd8fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608bd9000-00007ff608bd9fff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608bda000-00007ff608bdafff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608bdb000-00007ff608bdffff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608be0000-00007ff608be0fff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608be1000-00007ff608be1fff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608be2000-00007ff608be5fff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608be6000-00007ff608c2dfff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608c2e000-00007ffed19effff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ffed19f0000-00007ffed19f0fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed19f1000-00007ffed1af8fff 0x0020/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1af9000-00007ffed1b3cfff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b3d000-00007ffed1b45fff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b46000-00007ffed1b53fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b54000-00007ffed1b54fff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b55000-00007ffed1b57fff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b58000-00007ffed1bc1fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1bc2000-00007ffffffdffff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ffffffe0000-00007ffffffeffff 0x0001/0x0002 0x0020000
2cb4.2024: VirtualBox.exe: timestamp 0x5b4cb14e (rc=VINF_SUCCESS)
2cb4.2024: '\Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe' has no imports
2cb4.2024: '\Device\HarddiskVolume2\Windows\System32\ntdll.dll' has no imports
2cb4.2024: supR3HardNtChildPurify: cFixes=1 g_fSupAdversaries=0x8000
2cb4.2024: supR3HardNtChildPurify: Startup delay kludge #1/1: 520 ms, 61 sleeps
2cb4.2024: supHardNtVpScanVirtualMemory: enmKind=CHILD_PURIFICATION
2cb4.2024:  *0000000000000000-0000000000c4ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000c50000-0000000000c6ffff 0x0004/0x0004 0x0020000
2cb4.2024:  *0000000000c70000-0000000000c85fff 0x0002/0x0002 0x0040000
2cb4.2024:   0000000000c86000-0000000000c8ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000c90000-0000000000d8afff 0x0000/0x0004 0x0020000
2cb4.2024:   0000000000d8b000-0000000000d8dfff 0x0104/0x0004 0x0020000
2cb4.2024:   0000000000d8e000-0000000000d8ffff 0x0004/0x0004 0x0020000
2cb4.2024:  *0000000000d90000-0000000000d93fff 0x0002/0x0002 0x0040000
2cb4.2024:   0000000000d94000-0000000000d9ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000da0000-0000000000da1fff 0x0004/0x0004 0x0020000
2cb4.2024:   0000000000da2000-0000000000dfffff 0x0001/0x0000 0x0000000
2cb4.2024:  *0000000000e00000-0000000000f4efff 0x0000/0x0004 0x0020000
2cb4.2024:   0000000000f4f000-0000000000f51fff 0x0004/0x0004 0x0020000
2cb4.2024:   0000000000f52000-0000000000ffffff 0x0000/0x0004 0x0020000
2cb4.2024:   0000000001000000-000000007ffdffff 0x0001/0x0000 0x0000000
2cb4.2024:  *000000007ffe0000-000000007ffe0fff 0x0002/0x0002 0x0020000
2cb4.2024:   000000007ffe1000-000000007ffeffff 0x0000/0x0002 0x0020000
2cb4.2024:   000000007fff0000-00007ff60829ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ff6082a0000-00007ff6082c2fff 0x0002/0x0002 0x0040000
2cb4.2024:   00007ff6082c3000-00007ff608b1ffff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ff608b20000-00007ff608b20fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608b21000-00007ff608b91fff 0x0020/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608b92000-00007ff608b92fff 0x0040/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608b93000-00007ff608bd8fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608bd9000-00007ff608be5fff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608be6000-00007ff608c2dfff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Program Files\Oracle\VirtualBox\VirtualBox.exe
2cb4.2024:   00007ff608c2e000-00007ffed19effff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ffed19f0000-00007ffed19f0fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed19f1000-00007ffed1af8fff 0x0020/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1af9000-00007ffed1b3cfff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b3d000-00007ffed1b40fff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b41000-00007ffed1b45fff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b46000-00007ffed1b53fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b54000-00007ffed1b54fff 0x0004/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b55000-00007ffed1b57fff 0x0008/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1b58000-00007ffed1bc1fff 0x0002/0x0080 0x1000000  \Device\HarddiskVolume2\Windows\System32\ntdll.dll
2cb4.2024:   00007ffed1bc2000-00007ffffffdffff 0x0001/0x0000 0x0000000
2cb4.2024:  *00007ffffffe0000-00007ffffffeffff 0x0001/0x0002 0x0020000
2cb4.2024: supR3HardNtChildPurify: Done after 1101 ms and 1 fixes (loop #1).
203c.2e54: Log file opened: 5.2.16r123759 g_hStartupLog=0000000000000004 g_uNtVerCombined=0xa0383900
203c.2e54: supR3HardenedVmProcessInit: uNtDllAddr=00007ffed19f0000 g_uNtVerCombined=0xa0383900
203c.2e54: ntdll.dll: timestamp 0x59b0d03e (rc=VINF_SUCCESS)
203c.2e54: New simple heap: #1 0000000001100000 LB 0x400000 (for 1908736 allocation)
2cb4.2024: supR3HardNtEnableThreadCreation:
203c.2e54: supR3HardenedWinInitAppBin(0x0): '\Device\HarddiskVolume2\Program Files\Oracle\VirtualBox'
203c.2e54: System32:  \Device\HarddiskVolume2\Windows\System32
203c.2e54: WinSxS:    \Device\HarddiskVolume2\Windows\WinSxS
203c.2e54: KnownDllPath: C:\windows\System32
203c.2e54: supR3HardenedVmProcessInit: Opening vboxdrv stub...
203c.2e54: supR3HardenedVmProcessInit: Restoring LdrInitializeThunk...
203c.2e54: supR3HardenedVmProcessInit: Returning to LdrInitializeThunk...
203c.2e54: Registered Dll notification callback with NTDLL.
203c.2e54: supHardenedWinVerifyImageByHandle: -> 0 (\Device\HarddiskVolume2\Windows\System32\kernel32.dll)
203c.2e54: supR3HardenedWinVerifyCacheInsert: \Device\HarddiskVolume2\Windows\System32\kernel32.dll
203c.2e54: supR3HardenedMonitor_LdrLoadDll: pName=C:\windows\System32\KERNEL32.DLL (Input=KERNEL32.DLL, rcNtResolve=0xc0150008) *pfFlags=0xffffffff pwszSearchPath=0000000000004001:<flags> [calling]
2cb4.2024: supR3HardNtChildWaitFor[1]: Quitting: ExitCode=0xc0000005 (rcNtWait=0x0, rcNt1=0x0, rcNt2=0x103, rcNt3=0x103, 53 ms, CloseEvents);

Interesting... I'm dealing with the exact same issue and we have very similar setups. W10pro, Cylance. I installed a few Windows updates last week. Curious if you did the same?

KB4457128, KB4456655, KB4457146, KB4457128, KB4346783, KB4100347.

I've tried uninstall/reinstall VBox, deleted contents of the .VirtualBox folder and rebuilt, exited Cylance (doubt that did much), and ran "sfc /scannow".

I've everything except roll back to pre-Windows updates. Hesitant to do that because it's Monday and I have stuff to do.

Sorry I don't have any actual help to share but thought I'd post here too since our situation seems so similar.