Error while trying to run project: Unable to start program 'Mono'. Operation not supported. Unknown error: 0x80004005

I get this error just as I am deploying the .droid project in the solution:

Error while trying to run project: Unable to start program 'Mono'. Operation not supported. Unknown error: 0x80004005.

I'm running Visual Studio 2017 and deploying to a Samsung Galaxy Tab S2. It used to work fine before I upgraded from Visual Studio 2015.

The app installs on the device but does not run in debug when deploying.

Any help would be much appreciated.

I'm not able to comment so I'll post and answer.

Try to unninstall your app from your device.

1. Remove it on the settings section of your phone;
2. Go to internal extorage/android/data and remvove all folders related to your app (your app name).

Then try to run your application again from VS.