Microsoft EDGE - Security certificate required to access this resource is invalid

We are getting following error in Microsoft EDGE in our Dev environment when we run our ASP.NET Application Hosted in IIS 8 in Windows 2012 R2 Server.

Error: XMLHttpRequest: Network Error 0x800c0019, Security certificate required to access this resource is invalid.

Following are more details about implementations and environments. Our application runs on 2 different secured ports (HTTPS). In IIS both apps are hosting as different Web Applications and using same certificate. The certificate is generated using OpenSSL SHA2 encryption and it has been added in Secured Certificate Store.

From `Microsoft EDGE when we first load our application, it issues certificate warning message, and we are allowing to proceed. Once page is loaded, on a button click we are calling an API using AJAX call and that is hosted on different port.

In EDGE it is not allowing to proceed that API and giving above mentioned error.

In Chrome and IE 11 also, we are getting same warning message but from there it is allowing to execute next API.

Any help would be appreciated to fix the issue.

If you know your certificate is valid, a possible reason this might happen is if you have a tool running in the background somewhere that hijacks the SSL connections through a proxy, such as Fiddler.

Since such a tool is effectively using a man-in-the-middle attack to report the requests, the warnings are "normal". It's pretty easy to forget them running, too.