An unhandled exception occurred during the execution of the current web request

suddenly when i run my web application i get this error :

Could not load file or assembly 'file:///C:\Users\rafael\AppData\Local\Temp\Temporary ASP.NET Files\root\284bddf3\431c8965\App_Web_homepage.aspx.cdcab7d2.vmizb1js.dll' or one of its dependencies. The handle is invalid. (Exception from HRESULT: 0x80070006 (E_HANDLE))

Here's the stack trace:

FileLoadException: Could not load file or assembly 'file:///C:\Users\rafael\AppData\Local\Temp\Temporary ASP.NET Files\root\284bddf3\431c8965\App_Web_homepage.aspx.cdcab7d2.vmizb1js.dll' or one of its dependencies. The handle is invalid. (Exception from HRESULT: 0x80070006 (E_HANDLE))]
   System.Reflection.RuntimeAssembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks) +0
   System.Reflection.RuntimeAssembly.nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks) +39
   System.Reflection.RuntimeAssembly.InternalLoadAssemblyName(AssemblyName assemblyRef, Evidence assemblySecurity, StackCrawlMark& stackMark, Boolean forIntrospection, Boolean suppressSecurityChecks) +132
   System.Reflection.Assembly.Load(AssemblyName assemblyRef, Evidence assemblySecurity) +28
   System.CodeDom.Compiler.CompilerResults.get_CompiledAssembly() +93
   System.Web.Compilation.BuildProvider.CreateBuildResult(CompilerResults results) +60
   System.Web.Compilation.TemplateControlBuildProvider.CreateBuildResult(CompilerResults results) +36
   System.Web.Compilation.BuildProvider.GetBuildResult(CompilerResults results) +16
   System.Web.Compilation.BuildManager.CompileWebFile(VirtualPath virtualPath) +9086138
   System.Web.Compilation.BuildManager.GetVPathBuildResultInternal(VirtualPath virtualPath, Boolean noBuild, Boolean allowCrossApp, Boolean allowBuildInPrecompile, Boolean throwIfNotFound, Boolean ensureIsUpToDate) +320
   System.Web.Compilation.BuildManager.GetVPathBuildResultWithNoAssert(HttpContext context, VirtualPath virtualPath, Boolean noBuild, Boolean allowCrossApp, Boolean allowBuildInPrecompile, Boolean throwIfNotFound, Boolean ensureIsUpToDate) +111
   System.Web.Compilation.BuildManager.GetVirtualPathObjectFactory(VirtualPath virtualPath, HttpContext context, Boolean allowCrossApp, Boolean throwIfNotFound) +125
   System.Web.Compilation.BuildManager.CreateInstanceFromVirtualPath(VirtualPath virtualPath, Type requiredBaseType, HttpContext context, Boolean allowCrossApp) +52
   System.Web.UI.PageHandlerFactory.GetHandlerHelper(HttpContext context, String requestType, VirtualPath virtualPath, String physicalPath) +31
   System.Web.UI.PageHandlerFactory.System.Web.IHttpHandlerFactory2.GetHandler(HttpContext context, String requestType, VirtualPath virtualPath, String physicalPath) +40
   System.Web.HttpApplication.MapHttpHandler(HttpContext context, String requestType, VirtualPath path, String pathTranslated, Boolean useAppConfig) +167
   System.Web.HttpServerUtility.Execute(String path, TextWriter writer, Boolean preserveForm) +517

[HttpException (0x80004005): Error executing child request for /homepage.aspx.]
   System.Web.HttpServerUtility.Execute(String path, TextWriter writer, Boolean preserveForm) +816
   System.Web.HttpServerUtility.Transfer(String path, Boolean preserveForm) +57
   System.Web.HttpServerUtility.Transfer(String path) +32
   photography.Global.Application_BeginRequest(Object sender, EventArgs e) in F:\Web Prog\my work\mcpd\gallery\photography\photography\Global.asax.cs:27
   System.Web.SyncEventExecutionStep.System.Web.HttpApplication.IExecutionStep.Execute() +148
   System.Web.HttpApplication.ExecuteStep(IExecutionStep step, Boolean& completedSynchronously) +75

I have no idea what's it all about. So i'd be grateful if i got any help.

Do you have the option to stop and restart the website?

This should, in theory, recycle the application pool for your site, which might be enough to correct the problem.

I hope this will help to you.