How to create an instance of Excel if Excel is not installed

In my C# app, with the help of Excel Interop dll (as reference) i am reading/writing excel files. If I move this program to system where office/excel is not installed (think of clean machine), i am hitting with below error.

System.Runtime.InteropServices.COMException (0x80040154): Retrieving the COM class factory for component with CLSID {00024500-0000-0000-C000-000000000046} failed due to the following error: 80040154 Class not registered (Exception from HRESULT: 0x80040154 (REGDB_E_CLASSNOTREG)).

Above error is expected since there is no excel on target machine.
My question is, is there any other way to use my program apart from registering Interop dll on target machine?

My question is, is there any other way to use my program apart from registering Interop dll on target machine?

You are asking if there is any way to use your program, which uses Excel interop, when Excel is not installed on the computer running your program. The short answer is no. The longer answer is yes, if you are willing to refactor your program to not use interop.

You can use the OOXml SDK provided by Microsoft if the version of Excel you are targeting is 2007 and up. You can also use a third party library such as Aspose if you are willing to spend a little bit of money.

An example of using the OOXml SDK for inserting a spreadsheet into an excel file can be found in the microsoft docs.

// Given a document name, inserts a new worksheet.
public static void InsertWorksheet(string docName)
{
    // Open the document for editing.
    using (SpreadsheetDocument spreadSheet = SpreadsheetDocument.Open(docName, true))
    {
        // Add a blank WorksheetPart.
        WorksheetPart newWorksheetPart = spreadSheet.WorkbookPart.AddNewPart<WorksheetPart>();
        newWorksheetPart.Worksheet = new Worksheet(new SheetData());

        Sheets sheets = spreadSheet.WorkbookPart.Workbook.GetFirstChild<Sheets>();
        string relationshipId = spreadSheet.WorkbookPart.GetIdOfPart(newWorksheetPart);

        // Get a unique ID for the new worksheet.
        uint sheetId = 1;
        if (sheets.Elements<Sheet>().Count() > 0)
        {
            sheetId = sheets.Elements<Sheet>().Select(s => s.SheetId.Value).Max() + 1;
        }

        // Give the new worksheet a name.
        string sheetName = "Sheet" + sheetId;

        // Append the new worksheet and associate it with the workbook.
        Sheet sheet = new Sheet() { Id = relationshipId, SheetId = sheetId, Name = sheetName };
        sheets.Append(sheet);
    }
}